Modulation of Oxidative Stress Parameters by Treatment with Piper Betle Leaf in Streptozotocin Induced Diabetic Rats
نویسندگان
چکیده
Objectives: To study the effect of oral administration of Piper betle leaf powder suspension on lipid peroxidation and antioxidants in streptozotocin (STZ) diabetic rats. Methods: Male Wistar strain rats were orally administered the leaf suspension of P. betle, (75 and 150 mg/kg body weight) for 30 days. Plasma and erythrocytes were separated out and the liver and kidney were homogenized in ice-cold buffer and the assays of thiobarbituric acid reactive substances (TBARS), hydroperoxides, glutathione (GSH), superoxide dismutase (SOD EC 1.11.1.1), catalase (CAT EC 1.11.1.6) and glutathione peroxidase (GPx EC 1.11.1.9) were performed in the supernatant obtained from liver and kidney of control and STZ diabetic rats. Plasma TBARS, hydroperoxides, ascorbic acid and alphatocopherol were measured.
منابع مشابه
Modulatory Effect of Pioglitazone on Sperm Parameters and Oxidative Stress, Apoptotic and Inflammatory Biomarkers in Testes of Streptozotocin-Induced Diabetic Rats
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